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Effects of aortic perivascular adipose tissue (PVAT) and PVAT conditioned media (CM) on large elastic artery stiffness. A: ex vivo intrinsic mechanical stiffness in aortic segments cultured for 72 h in the presence (+) or absence (−) of PVAT from WT and LDLr−/− mice. B: intrinsic stiffness in aortic segments from WT mice treated with PVAT CM from WT or LDLr−/− mice for 72 h. Values are means ± SE; n = 5–7 mice/group. *P < 0.05 vs. WT + PVAT, WT − PVAT and LDLr−/− − PVAT; or vs. WT CM.
