Table 1.
Effects of different inhibitors on basal tone in human IAS
| Inhibitor | Mechanism of Action | % of Basal Tone |
|---|---|---|
| H-77 | renin inhibitor | 52.9 ± 2.0 |
| Captopril | ACE inhibitor | 82.7 ± 2.0 |
| Losartan | AT1-R antagonist | 75.6 ± 3.0 |
| BPB | PLA2 inhibitor | 33.0 ± 4.0 |
| Indomethacin | nonselective COX inhibitor | 17.0 ± 6.0 |
| Sc-560 + Rofecoxib | COX-1 + COX-2 inhibitors | 20.0 ± 1.7 |
| SQ29548 | TPR antagonist | 50.9 ± 4.0 |
| AL8810 | FPR antagonist | 35.2 ± 5.7 |
| Losartan + SQ29548 | 37.0 ± 4.0 | |
| SQ29548 + AL8810 | 25.2 ± 7.2 |
Values represent the residual % basal internal anal sphincter (IAS) tone (means ± SE) following the maximal effect of different inhibitors given either individually or in different combinations. Data given in results represent the absolute decrease in the IAS tone following these treatments. ACE, angiotensin-converting enzyme; BPB, 4-bromophenacylbromide; COX, cyclooxygenase; FPR, prostaglandin F2α receptor; TPR, TXA2 receptor.