Figure 1.

Changes of optimized metabolic content in Scenario B. The differences (errors) between the optimized metabolic content c_{sim, n} (red circle) as well as their lower and upper 95%-confidence limits (error bars) to the measured values c_{obs, n} were scaled by the measured standard deviation by $c_{obs.,n}^{*}=\frac{c_{obs,n}-c_{sim,n}}{{\sigma }_{c_{obs,n}}}$. All changes of the values by the optimization can be explained by measurements errors. Note that for the assumed normal distribution of the measurement errors, the 95% confidence intervals corresponds to 2 σ_{cobs., n}.