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. 2015 Jun 2;6:390. doi: 10.3389/fpls.2015.00390

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Copyright © 2015 Chen and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The information flow in the gene regulatory network related to leukemogenesis in the downstream of coupling signal transduction pathways in Figure 3. Each TF regulates other genes and acts as a gene of TF regulated by other TFs. The 18 leukemogenesis-related TFs and the regulations are determined by the TRANSFAC gene-regulation database and shown as follows: AP-2α, β-catenin, C/EBPα, p300, c-Myc, CREBs (ATF-4/CREB1/Luman/OASIS/CREB3L2/CREB-H/ AIBZIP/CREBPA), CSLs(RBP-JK/RBPJL), E2Fs (E2F1/E2F2/E2F3), Elk-1, c-Fos, HIF-1α, c-Jun, LEF-1, NF-κBs (NF-κB1/NF-κB1-p50/NF-κB2-p52, NF-κB2/ NF-κB2-p52/c-Rel/RelA-p65/RelB), Smad3, STATs (STAT1/STAT3/STAT5), TCFs (TCF-1/TCF-3/TCF-4), and p53.