Figure 5.

Signal transductivities of the proteins in p38 MAPK and PI3K-AKT coupling pathways contributing to loss of transductivity of TF p53 at the acute myeloid leukemia (AML) subtype when compared with normal type. The solid line represents the PPIs in the plasma membrane, while the dot-and-dash line represents the interactive contribution from the other pathways. The proteins underlined in red play an important role in dysfunction of the downstream TF. The other notations are shown at the top of the Figure. Stars ★ denote the locations at which the genetic mutations occur.