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. Author manuscript; available in PMC: 2016 Jun 15.
Published in final edited form as: Bioorg Med Chem. 2015 Apr 4;23(12):2786–2797. doi: 10.1016/j.bmc.2015.03.075

Figure 2. CD148 is a critical regulator of platelet Src family kinases and platelet reactivity.

Figure 2

Src family kinases (SFKs) are essential for initiating and propagating signals from a variety of platelet receptors, including: the low affinity immunoglobulin receptor FcγRIIA; the von Willebrand factor (vWF) receptor complex GPIb-IX-V; the collagen integrin α2β1; the collagen activation receptor complex GPVI-FcRγ; the integrin αIIbβ3, which binds a variety of extracellular matrix and plasma proteins including fibrinogen and vWF; and the podoplanin receptor CLEC-2. Dark green boxes in the cytoplasmic regions of FcγRIIA and the FcRγ denote immunoreceptor tyrosine-based activation motifs (ITAMs); the light green box in the cytoplasmic tail of CLEC-2 denotes a hemi-ITAM.