Table 1.
Selected GO terms enriched by biological process
| Biological Process | P Value | Gene # | Genes | |
|---|---|---|---|---|
| ENaC | protein refolding | 1.42 E-05 | 8 | SSA1, SSE2, HSP78, HSP104, CPR6, YDJ1, SSE1, HSP82 |
| protein folding | 0.00013 | 15 | SSA1, SSE2, AHA1, HSP78, BTN2, CHS7, HSP104, CPR6, ERO1, SIS1, YDJ1, HCH1, STI1, SSE1, HSP82 | |
| CFTR | protein folding | 3.10 E-11 | 24 | SSA1, HSP26, SSE2, PDI1, SSB1, AHA1, HSP78, SSA4, MDJ1, BTN2, EGD2, SBA1, SSA2, HSP104, CPR6, HSP60, ERO1, HSC82, SIS1, YDJ1, HCH1, STI1, SSE1, HSP82 |
| protein refolding | 2.40 E-09 | 11 | SSA1, SSE2, HSP78, MDJ1, HSP104, CPR6, HSP60, HSC82, YDJ1, SSE1, HSP82 | |
| de novo protein folding | 3.01 E-05 | 7 | SSB1, MDJ1, EGD2, HSP60, HSC82, YDJ1, HSP82 | |
| regulation of pH | 0.00014 | 10 | VMA2, VMA9, VMA1, VMA3, VMA8, VMA7, VMA10, VMA5, VMA4, BTN2 | |
| pH reduction | P < 0.00034 | 9 | VMA2, VMA9, VMA1, VMA3, VMA8, VMA7, VMA10, VMA5, VMA4 | |
| monovalent inorganic cation homeostasis | 0.0004 | 11 | VMA2, VMA9, VMA1, VMA3, VMA8, VMA7, VMA10, VMA5, VMA4, BTN2, COS3 | |
| cellular monovalent inorganic cation homeostasis | 0.00083 | 10 | VMA2, VMA9, VMA1, VMA3, VMA8, VMA7, VMA10, VMA5, COS3, VMA4 | |
| Kir2.1 | iron assimilation | 7.41 E-10 | 7 | SIT1, FTR1, ARN1, ARN2, FET3, FIT2, FIT3 |
| iron ion homeostasis | 1.47 E-07 | 9 | SIT1, FTR1, ARN1, ARN2, TIS11, FET3, FIT2, FIT3, ISU1 | |
| iron coordination entity transport | 6.32 E-05 | 5 | SIT1, ARN1, ARN2, FIT2, FIT3 | |
| iron ion transmembrane transport | 0.00166 | 3 | FTR1, FET3, FET4 | |
| siderophore transport | 2.88 E-06 | 5 | SIT1, ARN1, ARN2, FIT2, FIT3 | |
| cell wall organization or biogenesis | 8.25 E-06 | 14 | TIP1, SED1, ACT1, CRH1, BGL2, HSP150, CWP1, CWP2, PIR3, CCW12, EXG1, CCW14, HPF1, SRL1 | |
| metal ion/transition ion/cellular cation homeostasis | P < 0.00018 | 10 | IZH1, SIT1, FTR1, ARN1, ARN2, TIS11, FET3, FIT2, FIT3, ISU1 | |
| chemical and ion homeostasis | 2.60 E-05 | 12 | PMP3, IZH1 SIT1, FTR1, ARN1, ARN2, CWP2, TIS11, FET3, FIT2, FIT3, ISU1 | |
| cation homeostasis | 2.74 E-05 | 11 | IZH1, SIT1, FTR1, ARN1, ARN2, CWP2, TIS11, FET3, FIT2, FIT3, ISU1 |
Enriched gene ontology (GO) terms obtained after transcriptionally profiling αENaC, CFTR, and Kir2.1 expressing yeast. The subset of induced genes under each condition was analyzed for significant enrichment of GO terms by biological process (P < 0.05) as described in materials and methods. The list of GO terms was edited to eliminate those arising from potential secondary effects, as described in the text. A complete list of GO terms can be found in Supplemental File S3.