TABLE 3.
Clinical and demographic characteristics of large cohorts of patients with S. aureus infective endocarditisi
| Characteristic | Value reported in reference: |
|||||
|---|---|---|---|---|---|---|
| 125 | 170 | 146 | 173 | 171 | 172 | |
| No. of patients | 558 | 260 | 133 | 74 | 61 | 27 |
| Region | Multinational | Denmark | Spain | Finland | France | Australia |
| Study type | Multicenter | Multicenter | Single center | Multicenter | Single center | Single center |
| Period (yr) | 2000–2003 | 1982–1991 | 1985–2006 | 1999–2002 | 1990–2000 | 1991–2006 |
| Age (yr) | 57a | 68a | NA | 55b | 57b | 64a |
| No. (%) of patients | ||||||
| Males | 341 (61) | 145 (56) | 89 (77) | 47 (64) | 42 (69) | 18 (67) |
| With acquisition type | ||||||
| HCA | 218 (39) | 88c (33) | 29c (22) | 34c (46) | NA | 26 (96) |
| Community | 326 (58) | 172 (67) | 104 (78) | 40 (54) | NA | 1 (4) |
| IDU | 117 (21) | 0d (0) | 62 (47) | 20 (27) | NA | 1 (4) |
| On dialysis | 79 (14) | NA | NA | 6 (8) | 7 (11) | 1 (4) |
| With diabetes | 110 (20) | 35 (13) | 2 (6) | 19 (26) | 12 (20) | 8 (30) |
| With intravascular device | 159 (28) | 23 (9) | NA | 10 (14) | 11 (17) | 14 (52) |
| With native valve | 401 (72) | 215 (83) | 113 (85) | 57 (77) | 55 (90) | 17 (63) |
| With prosthetic valve | 86 (15) | 24 (9) | 20 (15) | 17 (23) | 6 (10) | 10 (37) |
| With location of vegetations | ||||||
| Aortic | 143 (29) | 84 (32) | 21 (16) | 26 (35) | 22 (36) | 6 (22) |
| Mitral | 224 (46) | 100 (38) | 42 (32) | 22 (30) | 28 (46) | 15 (56) |
| Tricuspid/pulmonary | 132 (27) | 13 (5) | 58 (47) | 16 (22) | 11 (18) | 2 (7) |
| With MRSA | 283/424 (67) | 0 (0) | 8 (6) | 0e (0) | NA | 27f (100) |
| With complication | ||||||
| Stroke | 119 (21) | 91 (35) | 30 (23) | 13 (18) | 21 (34) | 9 (35) |
| Cardiac failure | 161 (29) | 139 (53) | 36 (27) | NA | 19 (31) | 4 (15) |
| Intracardiac abscess | 71 (13) | NA | 12 (9) | 3 (4) | 14 (23) | 3 (12) |
| With in-hospital mortality | 125 (22) | 164g (63) | 37 (28) | 17h (23) | 21 (34) | 15 (66) |
| With surgery | 211 (38) | 27 (10) | 39 (29) | 7 (9) | 20 (33) | 16 (59) |
a
Median age.
b
Mean age.
c
For several studies, only nosocomial versus community-onset data were collected.
d
IDUs were excluded from the study.
e
MRSA was excluded from the study.
f
Only MRSA was reported in this study.
g
This study included 83 patients not clinically known to have S. aureus IE but who were subsequently diagnosed at autopsy.
h
This study referred to 28-day mortality.
i
HCA, health care associated; IDU, intravenous drug user; MRSA, methicillin-resistant S. aureus; NA, not available.