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Selectivity of compound 13 against a large panel of protein phosphatases
| PTPs | IC50 (μM) for 13 |
|---|---|
| UBLCP1 | 1.0 ± 0.05 |
| CDC14A | 7.2 ± 0.04 |
| PTPH1 | 13.9 ± 1.3 |
| PEZ | 8.3 ± 0.5 |
| LAR | >50 |
| LMWPTP | >50 |
| PTP1B | 12.8 ± 0.7 |
| STEP | >50 |
| TC-PTP | 10.1 ± 0.4 |
| Laforin | 10.3 ± 0.4 |
| VHR | 6.0 ± 0.5 |
| MKP5 | 5.7 ± 0.5 |
| VHZ | 11.4 ± 0.93 |
| SHP1 | 8.0 ± 0.12 |
| SHP2 | 5.4 ± 0.18 |
| HePTP | 8.7 ± 0.48 |
| PTPε | >50 |
| PTPγ | >50 |
| PP5 | >50 |
| Scp1 | >50 |
