Table 2.
Comparison of change scores between the three treatment groups
| Variable | CIT+PBO (n=48) |
MPH+PBO (n=48) |
MPH+CIT (n=47) |
P value | |||
|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | ||
| Psychiatric Symptoms | |||||||
| Hamilton Anxiety Rating Scale | −4.4 | .6 | −5.4 | .5 | −6.2 | .6 | .1 |
| Apathy Evaluation Scale | 7.1 | 1.5 | 7.1 | 1.4 | 9.1 | 1.4 | .5 |
| CGI- improvement* | −1.4 | .2 | −0.8 | 0.2 | −1.4 | .2 | .001 |
| Health-related quality of life | |||||||
| Short-Form Health Survey | |||||||
| Energy | 17.1 | 4.1 | 18.2 | 3.9 | 24.1 | 3.9 | .4 |
| Wellbeing | 25.0 | 3.6 | 13.9 | 3.5 | 28.5 | 3.5 | .01 |
| Role-Emotional | 28.8 | 6.7 | 26.3 | 6.4 | 42.6 | 6.4 | .2 |
*
Note: HDRS-24- Hamilton Depression Rating Scale-24 Item, CGI-Improvement – Clinical Global Impression-Improvement Scale; +A negative change score corresponds to an improvement from baseline to endpoint, except for the Apathy Evaluation Scale and Short-Form Health Survey scores.
Citalopram=CIT; Methylphenidate=MPH; Placebo=PBO; SD- standard deviation