Table 3.

Between-treatment comparison of cognitive z-score change by composite domain, and raw-score change by neuropsychological test

Variable	Citalopram+ Placebo (n=48)			Methylphenidate+ Placebo (n=48)			Citalopram+ Methylphenidate (n=47)			P Value
	Raw-score change by test	Z-score change	SE	Raw-score change by test	Z-score change	SE	Raw-score change by test	Z-score change	SE
Attention/Processing Speed		.24	.10		−.006	.09		.05	.09	.2
WAIS-III Digit Span	2.07			.25			.37
Trail Making Test A (sec)+	−6.25			−1.78			−.36
Stroop Color Trial	3.82			.52			−.4
Language		.26	.09		.23	.09		.27	.08	.9
FAS	3.5			4.09			3.48
Animal Naming Test	1.29			−.47			.73
Boston Naming Test	3.2			1.84			1.36
Executive Functioning		.13	.12		.28	.12		−.02	.11	.2
Trail Making Test B (sec)+	−21.71			−8.98			8.0
Stroop Color-Word	2.55			.82			−.19
Visuospatial Functioning		−.10	.11		.01	.11		.16	.10	.2
WAIS-III Block Design	1.56			2.55			−.1
RCFT Copy	.05			−.41			.71
Memory		−.03	.10		.12	.09		-.05	.09	.4
CVLT-2 Long Delay Free	.31			.11			−.39
RCFT 30-Minute Delay	3.09			2.34			1.28
Global Performance Score		.10	.05		.15	.05		.10	.05	.7

Note: The Stroop Interference score was used to develop the Executive Functioning composite score. That variable was not included in the raw-score change, as no raw score is generated. We instead include the raw-score change for the Color-Word trial as a reference. However, unlike the Stroop Interference score, this does not correct for time completed on control trials (color and word naming trials) of the Stroop Color and Word Test.

⁺A negative change score corresponds to an improvement from baseline to endpoint

Citalopram=CIT; Methylphenidate=MPH; Placebo=PBO; SE= standard error