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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: JAMA Intern Med. 2015 Jun 1;175(6):959–967. doi: 10.1001/jamainternmed.2015.0533

Table 4.

Stratified hazard ratios and 95% confidence intervals for leisure time physical activity and mortality

MET h/wk 0 0.1-<7.5 7.5-<15 15-<22.5 22.5-<40 40-<75 75+ p-interact
Age (years) <0.001
 <50 1.00 0.73 (0.61–0.87) 0.75 (0.62–0.90) 0.81 (0.65–1.01) 0.70 (0.56–0.89) 0.80 (0.61–1.03) 0.72 (0.47–1.11)
 50-<60 1.00 0.78 (0.74–0.83) 0.67 (0.64–0.71) 0.66 (0.62–0.70) 0.65 (0.61–0.69) 0.63 (0.54–0.72) 0.60 (0.43–0.84)
 60-<70 1.00 0.81 (0.78–0.83) 0.70 (0.68–0.72) 0.63 (0.61–0.65) 0.59 (0.57–0.61) 0.61 (0.56–0.66) 0.70 (0.57–0.86)
 70+ 1.00 0.77 (0.74–0.81) 0.65 (0.62–0.68) 0.62 (0.59–0.65) 0.60 (0.57–0.62) 0.54 (0.49––0.60) 0.67 (0.52–0.85)
Sex 0.002
 Male 1.00 0.82 (0.80–0.85) 0.71 (0.69–0.73) 0.63 (0.61–0.65) 0.61 (0.59–0.63) 0.62 (0.58–0.67) 0.74 (0.62–0.89)
 Female 1.00 0.77 (0.74–0.79) 0.67 (0.64–0.69) 0.64 (0.61–0.66) 0.60 (0.57–0.62) 0.59 (0.54–0.65) 0.61 (0.49–0.75)
Education 0.087
 High school or less 1.00 0.78 (0.76–0.81) 0.65 (0.63–0.68) 0.61 (0.59–0.64) 0.58 (0.56–0.61) 0.58 (0.52–0.66) 0.58 (0.40–0.85)
 Some college or post-high school 1.00 0.74 (0.71–0.77) 0.63 (0.61–0.65) 0.56 (0.54–0.59) 0.53 (0.51–0.55) 0.53 (0.48–0.59) 0.56 (0.43–0.71)
 College graduate 1.00 0.75 (0.72–0.79) 0.63 (0.61–0.66) 0.57 (0.54–0.59) 0.56 (0.53–0.58) 0.55 (0.50–0.60) 0.68 (0.55–0.83)
Race 0.237
 Non-Hispanic white 1.00 0.79 (0.78–0.81) 0.68 (0.67–0.70) 0.62 (0.61–0.64) 0.60 (0.59–0.61) 0.61 (0.57–0.64) 0.68 (0.59–0.78)
 African American 1.00 0.80 (0.71–0.91) 0.66 (0.58–0.76) 0.70 (0.61–0.81) 0.60 (0.51–0.69) 0.57 (0.38–0.85) 0.80 (0.42–1.52)
BMI (kg/m2) <0.001
 18.5-<25 1.00 0.78 (0.75–0.81) 0.66 (0.63–0.68) 0.59 (0.57–0.62) 0.56 (0.54–0.58) 0.54 (0.50–0.59) 0.63 (0.52–0.76)
 25-<30 1.00 0.79 (0.76–0.82) 0.70 (0.67–0.72) 0.64 (0.61–0.66) 0.62 (0.59–0.64) 0.67 (0.62–0.74) 0.76 (0.60–0.95)
 30+ 1.00 0.83 (0.79–0.86) 0.72 (0.68–0.75) 0.67 (0.64–0.71) 0.66 (0.63–0.69) 0.72 (0.61–0.85) 0.62 (0.39–1.01)
Smoking status <0.001
 Never 1.00 0.80 (0.76–0.83) 0.69 (0.66–0.72) 0.66 (0.63–0.69) 0.64 (0.61–0.67) 0.67 (0.61–0.74) 0.67 (0.53–0.86)
 Former 1.00 0.77 (0.75–0.79) 0.65 (0.63–0.67) 0.59 (0.57–0.61) 0.56 (0.54–0.58) 0.55 (0.51–0.59) 0.61 (0.51–0.74)
 Current 1.00 0.85 (0.81–0.89) 0.77 (0.73–0.81) 0.72 (0.68–0.76) 0.69 (0.65–0.72) 0.72 (0.61–0.84) 0.83 (0.59–1.18)
Heart disease <0.001
 No 1.00 0.80 (0.78–0.82) 0.70 (0.68–0.72) 0.65 (0.63–0.66) 0.62 (0.60–0.64) 0.62 (0.58–0.66) 0.69 (0.60–0.80)
 Yes 1.00 0.79 (0.75–0.83) 0.65 (0.62–0.68) 0.58 (0.55–0.61) 0.55 (0.52–0.58) 0.56 (0.48–0.65) 0.66 (0.45–0.98)
Previous cancer 0.217
 No 1.00 0.80 (0.78–0.82) 0.69 (0.68–0.71) 0.64 (0.62–0.65) 0.61 (0.59–0.63) 0.63 (0.59–0.67) 0.70 (0.61–0.82)
 Yes 1.00 0.79(0.75–0.83) 0.66 (0.63–0.70) 0.61 (0.57–0.65) 0.58 (0.54–0.61) 0.54 (0.47–0.62) 0.59 (0.41–0.84)

Multivariable models are stratified by cohort, and adjusted for age, gender, smoking (never, former, current, missing), alcohol (none, <15 grams/day, 15–30 grams/day, 30+ grams/day), education (dropout, high school, post high school education, some college, college graduate, post-college, missing), marital status (married, divorced, widowed, single, missing), history of cancer, history of heart disease, and body mass index (<18.5, 18.5–25, 25-<30, 30-<35, 35+ kg/m2). The variable used for stratification was not included in the given model.

Interaction was tested using a continuous leisure-time physical activity term and the exposure of interest, using a Wald test for dichotomous variables and a likelihood ratio test for multi-level variables.