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. 2015 Jun;62(6):1398–1404. doi: 10.1016/j.jhep.2014.12.034

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© 2015 European Association for the Study of the Liver. Elsevier B.V. All rights reserved.

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Fig. 1 — UDCA alters key determinants of hepatic bile acid and cholesterol homeostasis. (A) mRNA analysis of bile acid biosynthesis markers. Controls: n = 18; UDCA: n = 19. (B) Representative Western blots of CYP7A1, FXR and densitometry (all samples) of protein levels relative to β-actin. Controls: n = 7; UDCA: n = 6. (C) ABCD-assay indicating FXR activity. Controls: n = 7; UDCA: n = 6. (D) mRNA analysis of cholesterol biosynthesis markers. Controls: n = 18; UDCA: n = 19. (E) Representative Western blots of HMGCR, phosphorylation status of HMGCR (HMGCRp), LDLR and densitometry (all samples). Controls: n = 7; UDCA: n = 6. Mean values ± SD are expressed for all data. ^∗p ⩽0.05, ^∗∗p ⩽0.01 vs. control group.