Table 2.
Single point and two-point haplotype association results for T2D.
| SNP | Minor allele | Single point | Two-point | Haplotype | |||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | SNPs | Omnibus P |
Haplotype | Frequency | OR | P | ||
| rs3217986 | C | 1.03 (0.86–1.22) | 7.74 × 10−1 | rs3217986/rs523096 | 4.69 × 10−1 | AC/CT/AT | 0.48/0.08/0.44 | 1.05/1.05/0.95 | 0.31/0.61/0.22 |
| rs523096 | C | 1.04 (0.95–1.14) | 3.97 × 10−1 | rs523096/rs10965215 | 4.70 × 10−1 | CA/TA/CG/TG | 0.03/0.40/0.46/0.12 | 0.83/0.97/1.06/0.98 | 0.23/0.53/0.24/0.76 |
| rs10965215 | A | 0.96 (0.88–1.05) | 3.63 × 10−1 | rs10965215/rs564398 | 5.64 × 10−1 | GG/AA/GA | 0.46/0.42/0.12 | 1.05/0.96/0.98 | 0.29/0.36/0.82 |
| rs564398 | G | 1.05 (0.96–1.15) | 2.75 × 10−1 | rs564398/rs1333034 | 5.69 × 10−1 | AG/GA/AA | 0.12/0.46/0.43 | 0.97/1.05/0.96 | 0.71/0.29/0.41 |
| rs1333034 | G | 0.97 (0.84–1.12) | 6.96 × 10−1 | rs1333034/rs8181047 | 9.32 × 10−1 | AA/GG/AG | 0.34/0.11/0.55 | 1.02/0.98/1.00 | 0.76/0.74/0.97 |
| rs8181047 | A | 1.01 (0.92–1.12) | 7.78 × 10−1 | rs8181047/rs10811647 | 6.02 × 10−1 | GG/AC/GC | 0.40/0.34/0.26 | 0.96/1.01/1.04 | 0.35/0.78/0.44 |
| rs10811647 | G | 0.96 (0.87–1.05) | 3.51 × 10−1 | rs10811647/rs1333039 | 6.49 × 10−1 | CG/GC/CC | 0.44/0.40/0.17 | 1.04/0.96/1.01 | 0.44/0.36/0.86 |
| rs1333039 | G | 1.04 (0.95–1.14) | 4.35 × 10−1 | rs1333039/rs16905599 | 5.47 × 10−1 | CA/GG/CG | 0.06/0.44/0.50 | 1.05/1.04/0.95 | 0.62/0.40/0.28 |
| rs16905599 | A | 1.05 (0.87–1.26) | 6.20 × 10−1 | rs16905599/rs1333040 | 9.28 × 10−1 | AC/GC/GT | 0.06/0.39/0.56 | 1.03/1.00/0.99 | 0.78/0.99/0.86 |
| rs1333040 | C | 1.00 (0.91–1.09) | 9.72 × 10−1 | rs1333040/rs10757278 | 5.95 × 10−1 | CG/TG/CA/TA | 0.04/0.44/0.40/0.12 | 1.06/0.96/1.00/1.09 | 0.66/0.42/0.92/0.24 |
| rs10757278 | G | 0.97 (0.89–1.07) | 5.67 × 10−1 | rs10757278/rs10811658 | 3.46 × 10−1 | GA/AA/GG/AG | 0.16/0.14/0.32/0.38 | 0.89/0.94/1.04/1.06 | 0.10/0.42/0.49/0.28 |
| rs10811658 | A | 0.92 (0.83–1.02) | 9.85 × 10−1 | rs10811658/rs10811659 | 4.60 × 10−1 | AC/GC/AT/GT | 0.19/0.03/0.11/0.67 | 0.93/0.98/0.95/1.08 | 0.20/0.87/0.49/0.11 |
| rs10811659 | C | 0.93 (0.83–1.04) | 1.89 × 10−1 | rs10811659/rs10757282 | 1.98 × 10−1 | TC/CT/TT | 0.44/0.21/0.35 | 1.07/0.92/0.98 | 0.14/0.14/0.72 |
| rs10757282 | C | 1.08 (0.99–1.18) | 9.88 × 10−2 | rs10757282/rs10811661 | 2.05 × 10−3 | CT/TT/CC | 0.16/0.28/0.56 | 1.19/0.93/0.89 | 7.63 × 10−4/0.11/5.71 × 10−2 |
| rs10811661 | C | 0.89 (0.78–1.00) | 5.76 × 10−2 | rs10811661/rs1333051 | 8.58 × 10−2 | CT/CA/TA | 0.11/0.05/0.84 | 0.95/0.81/1.12 | 0.45/0.04/6.48 × 10−2 |
| rs1333051 | T | 0.95 (0.82–1.10) | 5.04 × 10−1 | rs1333051/rs2065501 | 5.05 × 10−1 | TA/AA/TC/AC | 0.03/0.29/0.08/0.60 | 0.92/1.08/0.95/0.96 | 0.61/0.15/0.57/0.38 |
| rs2065501 | A | 1.06 (0.96–1.17) | 2.36 × 10−1 | rs2065501/rs10757287 | 6.15 × 10−1 | AT/CT/AA/CA | 0.09/0.04/0.23/0.64 | 1.07/1.02/1.05/0.94 | 0.41/0.91/0.36/0.19 |
| rs10757287 | T | 1.05 (0.92–1.21) | 4.43 × 10−1 | n/a | n/a | n/a | n/a | n/a | n/a |
Association results for T2D from single and two-point haplotype analysis after correction for gender, age, and BMI. Top associated haplotype rs10757282 and rs10811661 is outlined.