Table 2. Different types of active ligands taken into in silico study, with their chemical formula and their predicted function in disrupting different stages of viral cycles.

S.No	Drug names	Chemical Formula	Viral step	References
1	Amantadine	C10H17N	Ion channels activities	[74]
2	Hexamethylene Chloride	C12H30Cl2N2	HCV particle production	[31, 74, 85]
3	NB-DNJ	C10H21NO4	Folding of viral envelope and production of viral particles	[29, 39, 78]
4	BIT225	C16H15N5O	Ion channels activities	[80]
5	Apigenin	C15H10O5	HCV infection	[74, 86]
6	EGCG	C22H18O11	Early step of entry glycoproteins (attachment)Cell-to-cell spreadClearance of cell culture	[64, 87]
7	Ladanein	C17H14O6	HCV entry	[88]
8	Luteolin	C21H20O11	Replication	[86]
9	Naringenin	C15H12O5	AssemblySecretion (core and HCV RNA)	[89, 90]
10	Quercetin	C15H10O7	HCV replicationHCV production	[91, 92]
11	Silymarin	C25H22O10	Entry (fusion)ReplicationRNA and protein expression	[37, 93, 94]
12	Honokiol	C18H18O2	EntryReplication	[95]
13	Nobelitin	C21H22O8	Replication	[96, 97]