Table 3.
Sputum Characteristics of TEA Clusters in the YCAAD Cohort
| Control Subjects (n = 12) | Cluster 1 (n = 34) | Cluster 2 (n = 19) | Cluster 3 (n = 47) | P Value | |
|---|---|---|---|---|---|
| Mucus cell concentration* | 40.86 ± 20.98 | 83.02 ± 105.75 | 89.23 ± 143.61 | 73.72 ± 62.48 | 0.63 |
| Squamous, % | 8.2 ± 6.7 | 7.9 ± 7.0 | 8.0 ± 5.9 | 9.2 ± 6.9 | 0.60 |
| Viability, % | 58.1 ± 9.6 | 56.5 ± 16.1 | 64.4 ± 11.9 | 61.7 ± 17.8 | 0.14 |
| Neutrophils, % | 34.6 ± 10.0 | 41.5 ± 13.0 | 41.9 ± 15.2 | 37.8 ± 14.6 | 0.34 |
| Eosinophil, % | 1.5 ± 1.8 | 5.8 ± 6.7 | 4.7 ± 5.9 | 5.2 ± 7.7 | 0.91 |
| Macrophage, % | 61.3 ± 11.8 | 50.9 ± 13.0 | 50.9 ± 16.0 | 55.4 ± 15.4 | 0.31 |
| Lymphocyte, % | 1.0 ± 0.9 | 1.3 ± 1.5 | 1.2 ± 1.0 | 1.3 ± 1.4 | 0.90 |
| Bronchial epithelial cell, % | 1.6 ± 4.3 | 0.8 ± 1.5 | 1.3 ± 3.3 | 0.4 ± 1.0 | 0.26 |
| RIN, mean | 7.6 ± 1.1 | 7.4 ± 1.2 | 7.5 ± 1.0 | 7.7 ± 1.4 | 0.1 |
Definition of abbreviations: RIN = RNA integrity number; TEA = transcriptomic endotypes of asthma; YCAAD = Yale Center for Asthma and Airway Diseases.
Data are means ± SD. P values for comparisons among TEA clusters were determined using Kruskal-Wallis or Cochran-Armitage test.
*
Cells per microliter × 104.