Table 4.
Top 10 Differentially Expressed Genes between TEA Cluster 1 and Control Subjects
| Gene Name | Gene Symbol | Biologic Processes | Function | Fold Change | P Value | FDR | PubMed References |
|---|---|---|---|---|---|---|---|
| Hemogen | HEMGN | Apoptosis | Transcription factor | 1.25 | 2.79 × 10−7 | 4.01 × 10−3 | 16 |
| Piccolo (presynaptic cytomatrix protein) | PCLO | Cytoskeleton organization, regulation of exocytosis | Protein | 1.21 | 6.26 × 10−7 | 4.01 × 10−3 | 26 |
| Cartilage-associated protein | CRTAP | Extracellular matrix organization | Scaffolding protein | −1.48 | 7.87 × 10−7 | 4.01 × 10−3 | 25 |
| Exosome component 9 | EXOSC9 | RNA processing | RNase complex component | −2.10 | 1.11 × 10−6 | 4.01 × 10−3 | 32 |
| Chromosome 9 open reading frame 173 | C9orf173 | NA | NA | 1.36 | 1.23 × 10−6 | 4.01 × 10−3 | 2 |
| Small nuclear RNA activating complex, polypeptide 5, 19 kD | SNAPC5 | DNA-dependent regulation of transcription | Transcription factor | −1.08 | 1.23 × 10−6 | 4.01 × 10−3 | 9 |
| Impact RWD domain protein | IMPACT | Negative regulation of protein phosphorylation | Enzyme | −2.12 | 1.44 × 10−6 | 4.01 × 10−3 | 11 |
| Solute carrier family 4, sodium bicarbonate cotransporter, member 4 | SLC4A4 | Sodium ion transport | Membrane transporter protein | 1.22 | 1.45 × 10−6 | 4.01 × 10−3 | 61 |
| Histidine decarboxylase | HDC | Histamine biosynthesis | Enzyme | 1.39 | 1.94 × 10−6 | 4.78 × 10−3 | 48 |
| Neuronal cell adhesion molecule | NRCAM | Neuron migration | Cell adhesion molecules | 1.19 | 2.29 × 10−6 | 5.08 × 10−3 | 40 |
Definition of abbreviations: FDR = false discovery rate; NA = not applicable; TEA = transcriptomic endotypes of asthma.