Table 5.
Top 10 Differentially Expressed Genes between TEA Cluster 3 and Control Subjects
| Gene Name | Gene Symbol | Biologic Processes | Functions | Fold Change | P Value | FDR | PubMed References |
|---|---|---|---|---|---|---|---|
| Heart development protein with EGF-like domains 1 | HEG1 | Endothelial cell angiogenesis | Cell adhesion molecules | 1.78 | 1.09 × 10−7 | 2.42 × 10−3 | 7 |
| Small nucleolar RNA, C/D box 104 | SNORD104 | RNA modification | Noncoding RNA | 2.58 | 2.46 × 10−7 | 2.73 × 10−3 | 2 |
| Dynein, axonemal, heavy chain 17 | DNAH17 | Ciliary motility | Microtubule-associated motor protein | 1.88 | 2.61 × 10−6 | 1.18 × 10−2 | 7 |
| Cbl proto-oncogene, E3 ubiquitin protein ligase B | CBLB | Regulation of T-cell anergy | Ubiquitin protein ligase | 2.04 | 2.95 × 10−6 | 1.18 × 10−2 | 93 |
| Defensin, β1 | DEFB1 | Innate immune response | Antimicrobial peptide | 2.85 | 2.97 × 10−6 | 1.18 × 10−2 | 133 |
| Nonprotein coding RNA 204 | NCRNA204 | NA | Noncoding RNA | 2.20 | 3.55 × 10−6 | 1.18 × 10−2 | 1 |
| Transcription elongation factor A (SII) N-terminal and central domain containing | TCEANC | RNA elongation | Transcription elongation factor | 2.22 | 6.58 × 10−6 | 1.82 × 10−2 | 10 |
| Radical S-adenosyl methionine domain containing 2 | RSAD2 | Regulation of Toll-like receptor 9 signaling pathway | Antiviral protein | 1.57 | 1.04 × 10−5 | 2.07 × 10−2 | 28 |
| Purinergic receptor P2Y, G-protein coupled, 14 | P2RY14 | Regulation of inflammation | UDP-glucose receptor | 5.14 | 1.04 × 10−5 | 2.07 × 10−2 | 31 |
| Malignant fibrous histiocytoma amplified sequence | MFHAS1 | Cell cycle | Protein | 4.14 | 1.11 × 10−5 | 2.07 × 10−2 | 11 |
Definition of abbreviations: EGF = epidermal growth factor; FDR = false discovery rate; NA = not applicable; TEA = transcriptomic endotypes of asthma.