Table 6.
Phenotypic Characteristics of TEA Clusters in the Asthma BRIDGE Cohort
| Cluster 1 (n = 266) | Cluster 2 (n = 105) | Cluster 3 (n = 499) | P Value | |
|---|---|---|---|---|
| Prevalence in cohort | 31% | 12% | 57% | <2.2 × 10−16 |
| Age at visit, yr | 14.8 ± 8 | 10.1 ± 5 | 12.6 ± 7 | 3.27 × 10−8 |
| Sex, n (%) female | 128 (48) | 45 (43) | 212 (43) | 0.31 |
| Race | 1.68 × 10−7 | |||
| White, n (%) | 102 (38) | 79 (75) | 284 (57) | |
| Black, n (%) | 105 (40) | 9 (9) | 124 (25) | |
| Other, n (%) | 29 (11) | 7 (7) | 37 (7) | |
| Hispanic origin, n (%) | 30 (11) | 10 (10) | 54 (11) | 0.09 |
| History of atopy, n (%) | 69 (26) | 40 (38) | 113 (23) | 0.0013 |
| Age of symptom onset | 3.50 ± 3.21 | 3.32 ± 2.89 | 3.48 ± 2.80 | 0.86 |
| History of hospitalization, n (%) | 91 (34) | 37 (35) | 128 (26) | 0.011 |
| History of intubations, n (%) | 21 (8) | 0 (0) | 9 (2) | 5.58 × 10−6 |
| ACT score | 14 ± 4 | 12 ± 3 | 13 ± 3 | 8.79 × 10−7 |
Definition of abbreviations: ACT = Asthma Control Test; BRIDGE = BioRepository for Integrative Genomic Exploration; TEA = transcriptomic endotypes of asthma.
Data are means ± SD, except where indicated.