Table 1.
Characteristics of Patients with Severe Sepsis
| Characteristic | Value |
|---|---|
| Age, yr | 3.0 (0.7–11.0) |
| Male sex, n (%) | 302 (53.3) |
| Race/ethnicity, n (%) | |
| White | 245 (43.2) |
| Hispanic | 97 (17.1) |
| Black | 79 (13.9) |
| Asian | 75 (13.2) |
| Other | 39 (6.9) |
| Unknown | 32 (5.6) |
| Comorbid conditions, n (%) | |
| Respiratory | 172 (30.3) |
| Gastrointestinal | 141 (24.9) |
| Cardiovascular | 136 (24.0) |
| Genetic | 115 (20.3) |
| Hematologic/immunologic | 114 (20.1) |
| Neuromuscular | 97 (17.1) |
| Neoplastic | 80 (14.1) |
| Prematurity | 76 (13.4) |
| Metabolic | 62 (10.9) |
| Renal | 55 (9.7) |
| Solid organ/stem cell transplant | 54 (9.5) |
| Number of comorbid conditions, n (%) | |
| None | 128 (22.6) |
| 1 | 141 (24.9) |
| ≥2 | 298 (52.6) |
| Admission POPC, n (%) | |
| Good performance | 290 (51.2) |
| Mild disability | 85 (15.0) |
| Moderate disability | 90 (15.9) |
| Severe disability or coma | 102 (18.0) |
| Lactate, maximum, mmol/L* | 1.8 (1.1–3.5) |
| ScvO2, minimum, %† | 66 (55–75) |
| PaO2/Fio2, minimum, mm Hg‡ | 158 (96–251) |
| PIM-3 score§ | 4.1 (1.7–8.7) |
| PELOD score║ | 11 (2–12) |
| Type of PICU admission, n (%) | |
| Medical | 460 (81.1) |
| Surgical, scheduled | 53 (9.4) |
| Surgical, unscheduled | 34 (6.0) |
| Trauma | 20 (3.5) |
| Source of admission, n (%) | |
| Emergency department¶ | 167 (29.5) |
| Hospital floor | 158 (27.9) |
| Operating room | 50 (8.8) |
| Other hospital** | 166 (29.3) |
| Other | 26 (4.6) |
| Organ dysfunction present at screening,†† n (%) | |
| Respiratory | 469 (82.7) |
| Cardiovascular | 398 (70.2) |
| Hematologic | 175 (30.9) |
| Hepatic | 143 (25.2) |
| Neurologic | 119 (21.0) |
| Renal | 93 (16.4) |
Definition of abbreviations: PELOD = Pediatric Logistic Organ Dysfunction; PICU = pediatric intensive care unit; PIM-3 = Pediatric Index of Mortality 3; POPC = Pediatric Overall Performance Category; ScvO2 = central venous oxygen saturation.
Data are presented as median (interquartile range), unless noted otherwise.
Lactate was measured in 391 of 567 patients.
ScvO2 was measured in 200 of 567 patients.
PaO2/Fio2 ratio was measured in 352 of 567 patients; it was not collected in patients with unpalliated cyanotic heart disease.
PIM-3 was measured at time of PICU admission.
PELOD score was calculated from data within a 48-hour time window around the study day (9:00 a.m. on the day before to 9:00 a.m. the day after the study day).
Emergency department at the same hospital as the PICU.
“Other hospital” includes emergency department at another hospital.
Based on organ dysfunction criteria defined by the 2005 International Pediatric Sepsis Consensus Conference (16).