Table 2.

Site of Infection and Microbiologic Etiology of Severe Sepsis

Characteristic	n (%)
Primary site of infection
Respiratory	228 (40.2)
Primary bloodstream	108 (19.1)
Abdominal	47 (8.3)
Central nervous system	25 (4.4)
Genitourinary	21 (3.7)
Skin	20 (3.5)
Other	29 (5.1)
Unknown	89 (15.7)
Microbiology*
Total patients with positive isolate†	371 (65.4)
Gram-negative bacteria	158 (27.9)
Pseudomonas species	45 (7.9)
Klebsiella species	36 (6.4)
Escherichia coli	32 (5.6)
Enterobacter species	17 (3.0)
Acinetobacter species	14 (2.5)
Other	55 (9.7)
Gram-positive bacteria	150 (26.5)
Staphylococcus aureus	65 (11.5)
Methicillin-resistant Staphylococcus aureus	20 (3.5)
Enterococcus species	25 (4.4)
Staphylococcus epidermis	21 (3.7)
Streptococcus pneumonia	10 (1.8)
Other	45 (7.9)
Anaerobic bacteria	1 (0.2)
Other bacteria	3 (0.5)
Fungi	76 (13.4)
Candida species	67 (11.8)
Aspergillus species	3 (0.5)
Other	8 (1.4)
Parasites	3 (0.5)
Viruses	119 (21.0)
Rhinovirus	32 (5.6)
Respiratory syncytial virus	22 (3.9)
Adenovirus	20 (3.5)
Cytomegalovirus	13 (2.3)
Influenza	12 (2.1)
Human metapneumovirus	12 (2.1)
Epstein-Barr virus	8 (1.4)
Other virus	27 (4.8)

^*Categories do not add up to 100% as some infections were polymicrobial.

^†Sources of positive isolates include blood, urine, cerebrospinal fluid, respiratory system (nasopharynx, tracheal, and bronchoalveolar lavage), stool, wound, and other normally sterile body fluids (pleural, pericardial, and peritoneal).