Table 4.
Outcomes for Total Cohort and by Age Category
| Age Categories |
||||||||
|---|---|---|---|---|---|---|---|---|
| Total | 0–28 d | 29 d to <1 yr | 1 to <5 yr | 5 to <10 yr | 10 to <15 yr | 15 to <18 yr | P Value* | |
| Vasoactive-free days, median (IQR) | 23 (12–28) | 20 (5–26) | 21 (1–27) | 25 (19–28) | 26 (20–28) | 25 (16–28) | 22 (12–28) | <0.001 |
| Ventilator-free days, median (IQR) | 16 (0–25) | 14 (0–23) | 4 (0–21) | 19 (2–25) | 22 (7–28) | 16 (0–28) | 16 (1–28) | <0.001 |
| New or progressive MODS† | 171 (30) | 10 (29) | 48 (34) | 37 (27) | 25 (29) | 32 (30) | 19 (31) | 0.89 |
| PICU mortality | 139 (24) | 9 (26) | 43 (31) | 26 (19) | 20 (23) | 26 (25) | 15 (24) | 0.42 |
| Hospital mortality | 145 (25) | 9 (26) | 43 (31) | 28 (21) | 20 (23) | 28 (26) | 17 (27) | 0.54 |
| At least mild disability‡ | 116 (28) | 8 (31) | 29 (30) | 31 (29) | 18 (27) | 16 (21) | 14 (31) | 0.73 |
| At least moderate disability§ | 73 (17) | 5 (19) | 17 (17) | 17 (16) | 13 (19) | 9 (12) | 12 (27) | 0.40 |
| Death or disability║ | 218 (38) | 14 (40) | 60 (43) | 45 (33) | 33 (38) | 37 (35) | 29 (47) | 0.41 |
Definition of abbreviations: IQR = interquartile range; MODS = multiorgan dysfunction syndrome; PICU = pediatric intensive care unit.
Data are presented as n (%), unless otherwise noted.
*
Kruskal-Wallis test or Fisher’s exact test across age categories.
†
New or progressive MODS was considered starting the day after sepsis recognition.
‡
Any increase in Pediatric Overall Performance Category (POPC) from baseline to hospital discharge in the 422 hospital survivors.
§
Discharge POPC ≥ 3 and an increase of ≥1 from baseline in the 422 hospital survivors.
║
Death or at least moderate disability at hospital discharge.