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. Author manuscript; available in PMC: 2015 Jun 2.

Published in final edited form as: Respir Physiol Neurobiol. 2013 Mar 5;186(3):255–264. doi: 10.1016/j.resp.2013.02.028

Table 2.

Effects of bolus injection of vehicle or test drugs on resting ventilatory parameters

		Peak Response, %		Cumulative Response, %
Study	Parameter	Vehicle	Drug	Vehicle	Drug
Naloxone	Frequency, breaths/min	+4 ± 4	+71 ± 19^*,^†	−2 ± 2	+36 ± 6^*,^†
	Tidal Volume, mls	−9 ± 9	+1 ± 4	−2 ± 1	−15 ± 3^*,^†
	Minute Ventilation, mls/min	+6 ± 8	+52 ± 11^*,^†	−4 ± 2	+15 ± 4^*,^†
Naltrindole	Frequency, breaths/min	+52 ± 8^*	+77 ± 13^*	+7 ± 3	+39 ± 4^*,^†
	Tidal Volume, mls	−16 ± 3^*	−15 ± 3^*	+3 ± 1	−8 ± 2^*,^†
	Minute Ventilation, mls/min	+24 ± 3^*	+54 ± 7^*,^†	+9 ± 2^*	+20 ± 2^*,^†
D-penicillamine	Frequency, breaths/min	+10 ± 6	+48 ± 6	+3 ± 4	+17 ± 4^*,^†
	Tidal Volume, mls	+1 ± 3	+6 ± 4	+1 ± 3	+1 ± 4
	Minute Ventilation, mls/min	+6 ± 4	+43 ± 7^*,^†	+3 ± 2	+18 ± 5^*,^†

The data are presented as mean ± SEM. There were six rats in each group.

^*

P < 0.05, significant response.

^†

P < 0.05, drug-treated versus vehicle-treated rats.