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. 2013 Mar 16;4(1-3):1–12. doi: 10.1007/s12645-013-0032-9

Table 1.

Stepwise optimization of variable parameters

Step	Formulation code	Variable parameters				Response parameters		Opt. parameter	Level of opt (code)
Step	Formulation code	Solid lipid (mg)	PluronicF68 (mg)	Homogenization time (min)	Sonication time (min)	Size range (nm) (Opt^a)	PDI range (Opt^b)	Opt. parameter	Level of opt (code)
Step 1	F1–F5	200	200	1–5	–	2,023–1,384 (1,023 ± 58.32)	0.321–0.202 (0.202 ± 0.44)	Homogenization time	3 min (F3)
Step 2	F6–F10	200	100–250	3	3	291.8–158.6 (101.3 ± 49.21)	0.363–0.202 (0.202 ± 0.004)	Surfactant concentration (F68)	200 mg (F9)
Step 3	F10–F15	200	200	3	2–5	368.4–168.1 (136.1 ± 4.16)	0.365–0.217 (0.217 ± 0.003)	Sonication time	4 min (F14)

^aThe lowest level optimized

^bValues based on size were optimized