Figure 1.

Chow-fed Dagla KO mice are lean. (A) Histogram of normalized% body fat for 3,651 knockout lines maintained on chow diet. Body composition analyses performed by DEXA on 14-week-old male mice fed chow diet from weaning were used to calculate normalized % body fat for each knockout line as described in Materials and Methods. The mean normalized % body fat value was 1.08 ± 0.15; the distribution was normal based on Kolmogorov–Smirnov testing (P < 0.01). Solid points indicate actual numbers of knockout lines. Curved line shows the calculated curve; the range for 1 and 2 SD from the mean are indicated by lines located below the curve, and values for Cnr1, Dagla, Daglb, and Napepld KO mice are indicated by lines shown above the curve. (B) Time course for body weight of chow-fed Dagla KO mice and their WT littermates. (C) Time course for body fat measured by QMR of chow-fed Dagla KO mice and their WT littermates. For each data point in (B,C), N = 7–15 mice. KO mice different from WT mice of the same age and gender, *P < 0.05, **P < 0.01, ***P < 0.001.