Figure 2.

Dagla KO mice are lean on various diets. (A) Time course for body weight of Dagla KO mice and their WT littermates fed HFD. (B) Time course for body fat measured by QMR of Dagla KO mice and their WT littermates fed HFD. For (A,B), N = 12–15 mice for each data point. Normalized data for (C) body weight, (D) body fat measured by QMR, and (E) LBM measured by QMR on 16-week-old Dagla KO mice (N = 131) and their WT littermates (N = 169) fed various diets. (F). Length of femurs from Dagla KO mice (N = 8 males and 6 females) and their WT littermates (N = 9 males and 8 females). KO mice different from WT mice of the same age and gender, *P < 0.05, **P < 0.01, ***P < 0.001.