Figure 5.

Fecal weight, fecal fat and VO₂ of Dagla KO mice, and activity levels of Dagla and Cnr1 KO mice. Fecal weight (A) and fecal fat (B) from HFD-fed, 8-week-old group-housed male Dagla KO (four cages) and WT littermate (five cages) mice; mice were housed three per cage. VO₂(C) and total activity (D) levels of HFD-fed, 45-week-old female Dagla KO mice (N = 6) and their WT littermates (N = 8) measured in Oxymax chambers over 24 h as described in the Section ‘Materials and Methods.’ (E) Total activity levels of HFD-fed, 30-week-old male Dagla KO mice (N = 9) and their WT littermates (N = 7), and (F) activity levels of HFD-fed, 30-week-old male Cnr1 KO mice (N = 5) and their WT littermates (N = 6), measured over 3 weeks in the ER-4000 physiological measurement system as described in the Section ‘Materials and Methods.’