Figure 6.
Improved OGTT and fasting serum lipid measurements in Dagla and Cnr1 KO mice. (A) Glucose excursions, and (B) 0 and 30 min insulin levels, from an OGTT performed on HFD-fed male Dagla KO mice (N = 12) and their WT littermates (N = 14) at 16 weeks of age. (C) Glucose excursions, and (D) 0 and 30 min insulin levels, from an OGTT performed on and independent cohort of HFD-fed male Dagla KO mice (N = 10) and their WT littermates (N = 6) at 18 weeks of age. (E) Glucose excursions, and (F) 0 and 30 min insulin levels, from an OGTT performed on HFD-fed male Cnr1 KO mice (N = 14) and their WT littermates (N = 15) at 16 weeks of age. For (A–F) above, KO glucose AUC and insulin levels different from WT, *P < 0.05, **P < 0.01. Normalized fasting serum triglyceride and total cholesterol levels from (G) adult Dagla KO mice (N = 47) and their WT littermates (N = 70), and (H) adult Cnr1 KO mice (N = 21) and their WT littermates (N = 26); KO different from WT, ***P < 0.001.