Table 1.
Body composition by QMR of Dagla KO and WT mice at >1 year of age.
| Cohort | Genotype | N | Age (months) | Body weight (g) | Body fat (g) | % Body fat | LBM (g) |
|---|---|---|---|---|---|---|---|
| 2-M | WT | 9 | 14 | 55.8 ± 8.4 | 19.8 ± 4.8 | 35.0 ± 5.5 | 36.0 ± 4.5 |
| 2-M | KO | 6 | 14 | 41.9 ± 5.8* | 13.1 ± 6.1* | 35.0 ± 7.3 | 28.8 ± 4.2** |
| 2-F | WT | 6 | 14 | 35.8 ± 7.7 | 11.1 ± 7.4 | 29.0 ± 12.9 | 24.7 ± 2.6 |
| 2-F | KO | 7 | 14 | 24.5 ± 2.1** | 3.9 ± 0.7* | 16.0 ± 1.9* | 20.6 ± 1.7** |
| 3-M | WF | 10 | 14 | 55.1 ± 6.5 | 21.1 ± 4.5 | 37.9 ± 4.1 | 34.0 ± 2.5 |
| 3-M | KO | 8 | 14 | 34.3 ± 6.9*** | 8.6 ± 4.6*** | 23.7 ± 8.0*** | 25.7 ± 2.5*** |
| 3-F | WF | 10 | 15 | 40.5 ± 9.4 | 15.4 ± 7.7 | 36.3 ± 9.5 | 25.1 ± 2.4 |
| 3-F | KO | 6 | 15 | 26.3 ± 4.2** | 6.0 ± 1.3* | 22.9 ± 2.7** | 20.3 ± 3.2** |
| 8-F | WT | 7 | 15 | 42.4 ± 9.3 | 16.8 ± 7.4 | 38.0 ± 9.7 | 25.6 ± 2.3 |
| 8-F | KO | 7 | 15 | 26.8 ± 2.9** | 5.1 ± 1.5** | 18.7 ± 3.8*** | 21.7 ± 1.7** |
Data presented as mean ± SD; N = number of mice; M = male; F = female; LBM, lean body mass. KO different from WF, *P < 0.05; **P < 0.01; ***P < 0.001.