TABLE 3 ] .
Sex, Age, y | Diagnosis | Peripheral Blood | Bone Marrow | Liver Function | Liver Biopsya | Transplant Candidacy |
M, 72 | IPF | Macrocytosis | Hypocellular | Normal | … | Listed no induction |
M, 58 | IPF | Normal | Normal | Normal | Marked regenerative changes | Listed |
M, 54 | CPFE | Macrocytosis | Hypocellular | Normal | … | Listed no induction |
F, 68 | IPF | Anemia, macrocytosis | Normal | Normal | Patchy mild portal chronic inflammation, spotty hepatocyte necrosis, and marked regenerative changes | Listed |
M, 71 | IPF | Anemia, macrocytosis | Plasmacytoma/MGUS | Normal | Mild regenerative changes | Not listed MGUS |
M, 58 | IPF | Anemia, macrocytosis | Hypocellular marrow. Erythroid dyspoiesis with megaloblastoid changesb | Normal | … | Not listed early MDS |
M, 58 | IPF | Anemia, macrocytosis, thrombocytopenia | Hypocellular with decreased megakaryocytes | Normal | … | Not listed. Decreased megakaryocytes on bone marrow biopsy |
F, 59 | IPF | Normal | Normal | Elevated enzymes, ALK P | Normal | Listed |
F, 66 | HP | Anemia, macrocytosis | Normal | Normal | Regenerative changes | Listed |
F, 51 | HP | Macrocytosis | Hypocellular | Low total protein | Regenerative changes | Listed no induction |
M, 48 | U | Macrocytosis | Normal | Normal | … | Listed |
M, 60 | CPFE | Macrocytosis | Hypocellular | Normal enzymes. Fatty liverc | Mild steatohepatitis. Moderate macrovesicular steatosis. Focal pericellular fibrosis. No cirrhosis. | Listed no induction |
M, 57 | U | Macrocytosis, thrombocytopenia | Hypocellular marrow/karyotypic changesd | Normal | … | Not listed (early MDS and severe right ventricular dysfunction) |
ALK P = alkaline phosphatase; F = female; M = male; MDS = myelodysplastic syndrome; MGUS = monoclonal gammopathy of undetermined significance; U = unclassified interstitial pneumonia. See Table 1 legend for expansion of other abbreviations.
Seven subjects underwent liver biopsies, since it was believed not to influence management.
Could represent early myelodysplastic syndrome.
By abdominal ultrasonography.
Early myelodysplastic syndrome. Trisomy 1q and monosomy 7q.