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. 2014 Nov 13;147(6):1549–1557. doi: 10.1378/chest.14-0631

TABLE 3 ] .

Outcome of Evaluation of Short Telomeres on Lung Transplant Candidacy

Sex, Age, y Diagnosis Peripheral Blood Bone Marrow Liver Function Liver Biopsya Transplant Candidacy
M, 72 IPF Macrocytosis Hypocellular Normal Listed no induction
M, 58 IPF Normal Normal Normal Marked regenerative changes Listed
M, 54 CPFE Macrocytosis Hypocellular Normal Listed no induction
F, 68 IPF Anemia, macrocytosis Normal Normal Patchy mild portal chronic inflammation, spotty hepatocyte necrosis, and marked regenerative changes Listed
M, 71 IPF Anemia, macrocytosis Plasmacytoma/MGUS Normal Mild regenerative changes Not listed MGUS
M, 58 IPF Anemia, macrocytosis Hypocellular marrow. Erythroid dyspoiesis with megaloblastoid changesb Normal Not listed early MDS
M, 58 IPF Anemia, macrocytosis, thrombocytopenia Hypocellular with decreased megakaryocytes Normal Not listed. Decreased megakaryocytes on bone marrow biopsy
F, 59 IPF Normal Normal Elevated enzymes, ALK P Normal Listed
F, 66 HP Anemia, macrocytosis Normal Normal Regenerative changes Listed
F, 51 HP Macrocytosis Hypocellular Low total protein Regenerative changes Listed no induction
M, 48 U Macrocytosis Normal Normal Listed
M, 60 CPFE Macrocytosis Hypocellular Normal enzymes. Fatty liverc Mild steatohepatitis. Moderate macrovesicular steatosis. Focal pericellular fibrosis. No cirrhosis. Listed no induction
M, 57 U Macrocytosis, thrombocytopenia Hypocellular marrow/karyotypic changesd Normal Not listed (early MDS and severe right ventricular dysfunction)

ALK P = alkaline phosphatase; F = female; M = male; MDS = myelodysplastic syndrome; MGUS = monoclonal gammopathy of undetermined significance; U = unclassified interstitial pneumonia. See Table 1 legend for expansion of other abbreviations.

a

Seven subjects underwent liver biopsies, since it was believed not to influence management.

b

Could represent early myelodysplastic syndrome.

c

By abdominal ultrasonography.

d

Early myelodysplastic syndrome. Trisomy 1q and monosomy 7q.