| In patients with nonvalvular atrial fibrillation, maintaining stable, therapeutic levels of anticoagulation for stroke prevention is challenging. |
| Even after 6 months of warfarin therapy, approximately 40 % of international normalized ratio (INR) values were out of the therapeutic range of 2.0–3.0. In addition, patients exposed to INR >4.0 consumed more healthcare resources. |
| Patient characteristics were not predictive of increased risk of over-anticoagulation, emphasizing the unpredictability of warfarin. |
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