Table 4.
Patient and tumor characteristics between Mutant and Wild Type KRAS patient populations
| KRASG12D n = 9 |
KRASnon-G12D n = 16 |
KRASWT n = 50 |
P Value
|
||
|---|---|---|---|---|---|
| G12 D vs. nonG12 D | G12D vs. WT | ||||
| Mean age at presentation, (Range) | 70 (58 – 92) | 66 (34 – 84) | 70 (41 – 86) | ||
| Symptomatic at diagnosis, n (%) | 9 (100) | 16 (100) | 31 (81.6) | Constant | 0.019** |
| Median tumor diameter, mm, (95% CI) | 25.1 (13.4 – 36.8) | 23 (16.9 – 29.1) | 18.4 (13.4 – 23.4) | 0.677 | 0.258 |
| T stage, n (%) | |||||
| T1 | 0 (0) | 6 (37.5) | 15 (30) | 0.011** | 0.012** |
| T2 | 3 (33.3) | 1 (6.3) | 10 (20) | ||
| T3 | 1 (11.1) | 7 (43.8) | 21(42) | ||
| T4 | 5 (55.6) | 2 (12.5) | 4 (8.0) | ||
| Node Status | |||||
| Node positive, n (%) | 3 (33.3) | 7 (43.8) | 16 (32) | 0.768 | 0.825 |
| Overall stage, n (%) | |||||
| I – IIA | 4 (44.4) | 9 (56.3) | 32 (64) | 0.572 | 0.271 |
| IIB – IIIB | 5 (55.6) | 7 (43.7) | 18 (36) | ||
| Perineural invasion | |||||
| Present, n (%) | 3 (33.3) | 5 (31.3) | 10 (20) | 0.772 | 0.312 |
| Vascular invasion | |||||
| Present, n (%) | 2 (22.2) | 3 (18.8) | 6 (12) | 0.835 | 0.410 |
| Epithelial Type, n (%) | |||||
| Intestinal | 5 (55.6) | 12 (75) | 37 (74) | 0.193 | 0.206 |
| Pancreatobiliary | 4 (44.4) | 3 (18.8) | 10 (20) | ||
| Mixed | 0 | 1 (6.2) | 3 (6) | ||
G12D = Asp for Gly substitution on codon 12, WT = wild type,
**
statistically significant,
*
borderline significant