Table 5.
Results of day 7 healing rate estimation for ACV and IDU with non-linear-mixed effect (NLME) model
| Group | # of Articles included | Total number of Subjects | point estimate(95% confidence interval) | |||
|---|---|---|---|---|---|---|
| ACV | IDU | Scale | ACV | IDU | ||
| Herpetic keratitis | 7 | 214 | 218 | Odds | 3.70 (2.02, 6.78) | 0.89 (0.51, 1.55) |
| Log Odds | 1.31 (0.70, 1.91) | −0.12 (−0.68, 0.44) | ||||
| Healing Rate | 0.79 (0.67, 0.87) | 0.47 (0.34, 0.61) | ||||
| Dendritic ulcers | 4 | 94 | 91 | Odds | 6.63 (1.43, 30.71) | 1.26 (0.32, 4.98) |
| Log Odds | 1.89 (0.36, 3.42) | 0.23 (−1.15, 1.60) | ||||
| Healing Rate | 0.87 (0.59, 0.97) | 0.56 (0.24, 0.83) | ||||
| Geographic ulcers | 3 | 13 | 22 | Odds | 1.17 (0.11, 12.78) | 0.22 (0.02, 2.40) |
| Log Odds | 0.15 (−2.24, 2.55) | −1.50 (−3.88, 0.87) | ||||
| Healing Rate | 0.54 (0.10, 0.93) | 0.18 (0.02, 0.71) | ||||
| Sensitivity Analysis (without data from [22]) | ||||||
| Herpetic keratitis | 6 | 184 | 189 | Odds | 3.12 (1.55, 6.30) | 1.06 (0.55, 2.05) |
| Log Odds | 1.14 (0.44, 1.84) | 0.06 (−0.61, 0.72) | ||||
| Healing Rate | 0.76 (0.61, 0.86) | 0.51 (0.35, 0.67) | ||||
| Dendritic ulcers | 3 | 64 | 62 | Odds | 4.08 (0.43, 38.79) | 2.50 (0.29, 21.88) |
| Log Odds | 1.41 (−0.84, 3.66) | 0.92 (-1.25, 3.09) | ||||
| Healing Rate | 0.80 (0.30, 0.97) | 0.71 (0.22, 0.96) | ||||