Table 4. Association of patient characteristics with candidacy for a short (9-month) regimen or a BDQ-containing regimen among patients with MDR TB*.
| Characteristic | Patient candidate, no. (%) |
p value | ||
|---|---|---|---|---|
| Total | Short regimen | BDQ-containing regimen | ||
| Sex | ||||
| M | 804 | 613 (76.2) | 191 (23.8) | 0.72 |
| F | 450 | 339 (75.3) | 111 (24.7) | |
| Employment status | ||||
| Unemployed | 475 | 328 (69.1) | 147 (30.9) | <0.001 |
| Disabled, retired, student, housewife | 192 | 150 (78.1) | 42 (21.9) | 0.37 |
| Employed | 581 | 471 (81.1) | 110 (18.9) | |
| History of imprisonment | ||||
| Yes | 81 | 50 (61.7) | 31 (38.3) | 0.001 |
| Unknown | 181 | 130 (71.8) | 51 (28.2) | 0.08 |
| No | 992 | 772 (77.8) | 220 (22.2) | |
| Homeless | ||||
| Yes | 29 | 21 (72.4) | 8 (27.6) | 0.54 |
| Unknown | 137 | 91 (66.4) | 46 (33.6) | 0.005 |
| No | 1,088 | 840 (77.2) | 248 (22.8) | |
| Alcohol abuse | ||||
| Yes | 186 | 108 (58.1) | 78 (41.9) | <0.001 |
| Unknown | 52 | 31 (59.6) | 21 (40.4) | <0.001 |
| No | 1,016 | 813 (80) | 203 (20) | |
| HIV status | ||||
| Positive | 159 | 108 (67.9) | 51 (32.1) | 0.88 |
| Unknown | 468 | 422 (90.2) | 46 (9.8) | <0.001 |
| Negative | 627 | 422 (67.3) | 205 (32.7) | |
| Any co-morbidity other than HIV infection | ||||
| Yes | 335 | 257 (76.7) | 78 (23.3) | 0.69 |
| No | 919 | 695 (75.6) | 224 (24.4) | |
| Classification by prior treatment history | ||||
| Received first-line drugs | 879 | 719 (81.8) | 160 (18.2) | <0.001 |
| Received second-line injectable drugs | 185 | 103 (55.7) | 82 (44.3) | 0.04 |
| New case | 168 | 112 (66.7) | 56 (33.3) | |
| Classification by prior TB treatment outcome | ||||
| Relapse | 181 | 124 (68.5) | 57 (31.5) | 0.66 |
| Failure, loss to follow up, change to second-line regimen | 598 | 444 (74.2) | 154 (25.8) | 0.04 |
| Chronic | 190 | 172 (90.5) | 18 (9.5) | <0.001 |
| Unknown | 119 | 102 (85.7) | 17 (14.3) | <0.001 |
| New case | 166 | 110 (66.3) | 56 (33.7) | |
| Body mass index | ||||
| <18.5 | 471 | 369 (78.3) | 102 (21.7) | 0.12 |
| >18.5 | 783 | 583 (74.5) | 200 (25.5) | |
| Site of TB disease | ||||
| Extrapulmonary and pulmonary | 57 | 45 (78.9) | 12 (21.1) | 0.59 |
| Pulmonary only | 1,195 | 906 (75.8) | 289 (24.2) | |
| Bilateral TB disease | ||||
| Yes | 993 | 748 (75.3) | 245 (24.7) | 0.48 |
| No | 236 | 183 (77.5) | 53 (22.5) | |
| Cavities on chest radiograph | ||||
| Unilateral | 477 | 339 (71.1) | 138 (28.9) | <0.001 |
| Bilateral | 293 | 210 (71.7) | 83 (28.3) | <0.001 |
| No | 484 | 403 (83.3) | 81 (16.7) | |
| AFB smear at the start of MDR treatment | ||||
| Positive | 1,063 | 810 (76.2) | 253 (23.8) | 0.37 |
| Negative | 155 | 113 (72.9) | 42 (27.1) | |
*Row percentages show proportion of patients with each characteristic that would be candidates for a particular regimen. AFB, acid-fast bacilli; BDQ, bedaquiline; MDR, multidrug-resistant; TB, tuberculosis.Bold type indicates statistical significance.