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. 2014 Aug 1;2:24. doi: 10.1186/2052-8426-2-24

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© Mariotti et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Relative efficiency of drug delivery in cells or alone. Left: Shows the low efficiency of drugs entering the brain due to the protection of the BBB. Right: Shows the potential to increase the efficiency of drug delivery when the drug is applied within MSCs. Center: Shown is the efficiency of CAR T-cells to enter the brain.