Table 4.

Possible transcription factor binding sites identified by JASPAR.

Transcription factor	Accessiona	Score	Relative scoreb	Binding site sequence	Corresponding CpG sitec
SP1	P08047	7.430	0.87	GCTCTGCCTCC
NFATC2	Q13469	6.016	0.80	TTCTCCT
SOX10	NP_008872	6.636	0.90	TTTTGT/CCGTGT	I
NF-kB	NP_003989	9.015	0.85	GGGGTTTCAC	G*
YY1	P25490	8.084	0.84	CAGGATGGTCTC	I
USF1	BAA76541	5.780	0.85	ATCTCCTGACC
Myc-Max	AAH36092	8.449	0.81	GACCTCGTGAT	J*
SP2	Q02086	6.046	0.81	CACCCGCCTTGGCCT	K*

^*The corresponding CpG sites reached the statistical significance in Table 2 or Table 3.

^aAccession number is the NCBI protein accession number.

^bThe relative score is provided by the JASPAR according to the similarity of motif sequence.

^cThe sequence in our study is listed as follows:

TGCAAGCTCTGCCTCCCG ^AGGTTCACG ^BCCATTCTCCTGCCTCAGCCTCCCG ^CAGTAGCTGGGACTATCTGCCACCG ^D CG ^ECCCG ^F GCTAAATTTTTTTTGTATTATTAGTAGAGACG ^GGGGTTTCACCG ^HTGTTAGCCAGGATGGTCTCG ^IATCTCCTGACCTCG ^J TGATCCACCCG ^KCCTTGGCCTCCCAAAG.

The sites marked as A–K are the methylation loci.