Table 3.
FGF21-induced effects on genes for hypothalamic neuropeptides.
| Gene of interest | N-PBS | N-FGF21 | Tg-PBS | Tg-FGF21 |
|---|---|---|---|---|
| AgRP | 1 ± 0.11 | 1.17 ± 0.08 | 0.93 ± 0.21 | 0.86 ± 0.10 |
| POMC | 1 ± 0.17 | 1.22 ± 0.09 | 1.04 ± 0.09 | 1.32 ± 0.14 |
| CART | 1 ± 0.01 | 1.01 ± 0.08 | 0.92 ± 0.11 | 1.08 ± 0.03 |
| NPY | 1 ± 0.06 | 1.04 ± 0.02 | 1.14 ± 0.13 | 1.17 ± 0.09 |
| MCH | 1 ± 0.12 | 0.95 ± 0.08 | 1.12 ± 0.04 | 1.26 ± 0.09 |
| Orexin | 1 ± 0.10 | 1.17 ± 0.12 | 1.09 ± 0.05 | 1.21 ± 0.14 |
| LEPR | 1 ± 0.12 | 1.21 ± 0.07 | 1.49 ± 0.29 | 1.77 ± 0.33 |
Shown is RT-PCR analysis of gene expression in normal and GH transgenic mice treated with FGF21 and vehicle (mean ± SEM, n = 5).