Table 3.
Distribution of CD4+ lymphocyte subpopulations in peripheral blood of pSS patients and controls.
| Patients | 1I-controls | 2II-pSS Abs− | 3III-pSS Abs+ | P * | P * | P * |
|---|---|---|---|---|---|---|
| I-II | I-III | II-III | ||||
| CD4+ lymphocyte populations | ||||||
| CD4+CD25+ | ||||||
| %4 | 10.00 ± 10.94 | 9.72 ± 6.1 | 11.64 ± 9.38 | NS | NS | NS |
| A. count# | 183.6 ± 222.3 | 132.7 ± 106.0 | 106.1 ± 75.89 | NS | 0.036 | NS |
| CD4+CD25high | ||||||
| %4 | 1.97 ± 1.342 | 2.45 ± 1.71 | 2.71 ± 1.83 | NS | NS | NS |
| A. count# | 32.13 ± 25.88 | 31.81 ± 25.92 | 24.39 ± 13.50 | NS | NS | NS |
| CD4+FoxP3 | ||||||
| %4 | 4.56 ± 4.73 | 5.19 ± 6.69 | 5.012 ± 4.68 | NS | NS | NS |
| A. count# | 75.25 ± 82.62 | 59.45 ± 72.83 | 62.62 ± 105.0 | NS | NS | NS |
| CD4+CD25+FoxP3 | ||||||
| %4 | 1.12 ± 2.09 | 1.10 ± 0.90 | 0.90 ± 0.63 | NS | NS | NS |
| A. count# | 19.12 ± 42.33 | 13.19 ± 10.79 | 10.21 ± 13.65 | NS | NS | NS |
| CD4+CD25highFoxP3 | ||||||
| %4 | 0.27 ± 0.34 | 0.36 ± 0.31 | 0.35 ± 0.27 | NS | NS | NS |
| A. count# | 4.45 ± 6.9 | 4.039 ± 2.91 | 3.26 ± 2.81 | NS | NS | NS |
| CD4+CD25lowFoxP3 | ||||||
| %4 | 0.84 ± 1.75 | 0.78 ± 0.73 | 0.57 ± 0.51 | NS | NS | NS |
| A. count# | 14.57 ± 35.46 | 9.64 ± 9.612 | 6.71 ± 12.78 | NS | 0.017 | NS |
| Th17 | ||||||
| %4 | 2.08 ± 1.31 | 0.85 ± 1.08 | 1.51 ± 2.89 | 0.0003 | 0.004 | NS |
| A. count# | 34.44 ± 21.02 | 9.12 ± 10.89 | 10.89 ± 22.71 | <0.0001 | <0.0001 | NS |
1I group: healthy controls; 2II group: pSS patients without anti-SSA/SSB; 3III group: pSS patients with anti-SSA and/or anti-SSB; %4: proportion of all CD4+ lymphocytes; A. count#: absolute count of cells in 1 μL of blood. *Mann-Whitney test. NS: not significant.