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. Author manuscript; available in PMC: 2015 Jun 2.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Apr 5;19(14):3866–3869. doi: 10.1016/j.bmcl.2009.03.153

Figure 1.

Figure 1

(A) Schematic representation of a strategy for isolating improved ligands. A modest-affinity lead compound is conjugated to each peptoid on a microarray by click chemistry. The slide is subsequently incubated with a target protein under stringent condition to provide a high-affinity ligand. (B) Microarray images of the hit compounds (spotted in duplicate) were obtained by incubating fluorescently labeled KIX-His6 on a microarray in which each peptoid molecule is capped with BHK2.