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. Author manuscript; available in PMC: 2015 Jun 2.
Published in final edited form as: J Biomed Inform. 2013 Apr 6;46(4):585–593. doi: 10.1016/j.jbi.2013.04.001

Table 4.

Comparison of bootstrapping approach with the dictionary-based approach with drugs and genes from PharmGKB PGx-specific drug-gene pairs as input.

Method Cutoff (%) N Precision Recall F1
Bootstrapping (Seed “Warfarin–CYP2C9”) 50 1,311 0.354 0.297 0.323
100 2,622 0.219 0.368 0.274
Bootstrapping (Seeds 68 FDA drug-gene pairs) 50 2,383 0.260 0.397 0.314
100 4,767 0.171 0.522 0.258
Dictionary-based Approach 50 6,222 0.178 0.711 0.285
100 12,444 0.125 1.000 0.223
None (co-occurrence with 19,055 genes and 6,516 drugs) 50 51,458 0.024 0.783 0.046
100 102,916 0.015 1.000 0.030