Figure 2. Trends in mean CD8⁺ and CD4⁺ T cells following antiretroviral therapy.

The y axis shows change in total cells/mm³ for CD4⁺ T-cell subsets (panel A), change in CD4⁺ T-cell in HIV⁺ subjects with baseline CD4⁺ T-cells >500 cells/mm³ (panel B), and with baseline CD4⁺ T-cells ≤ 500 cells/mm³ (panel C). Change in CD8⁺ T-cell subsets (panel D), CD8⁺ T-cell subsets in HIV⁺ subjects with baseline CD4⁺ T-cells > 500 cells/mm³ (panel E), and with baseline CD4⁺ T-cells ≤ 500 cells/mm³ (panel F) are also shown. Bars represent baseline (), week 12 (), week 24 (), week 48 (), and HIV ⁻ controls () and are shown for each subset. Significant changes over 48 weeks are shown with arrows. Changes from entry to 48 weeks among HIV⁺ subjects are represented with (*) (p<0.05, Wilcoxon Rank-Sum test). Significant differences between HIV⁺ subjects at baseline to HIV⁻ controls and HIV⁺ subjects at 48 weeks to HIV⁻ controls are shown with (†) and (‡), respectively (p<0.05, Wilcoxon Rank-Sum test). Error bar indicates 1 standard deviation.