Table III.
Growth trajectories and bronchial responsiveness at age 8 years and bronchial reversibility at age 15 years
| Methacholine responsive at 8 y n = 4389 | P value | Salbutamol responsive at 15 y n = 3750 | P value | |
|---|---|---|---|---|
| Height | ||||
| Birth length (SD) | 1.00 (0.90-1.11) | .98 | 1.01 (0.84-1.21) | .95 |
| 0-3 mo (SD/mo) | 0.96 (0.89-1.04) | .31 | 1.12 (0.97-1.29) | .12 |
| 3-12 mo (SD/mo) | 0.99 (0.89-1.11) | .88 | 1.06 (0.87-1.28) | .59 |
| 1-3 y (SD/mo) | 1.01 (0.92-1.10) | .82 | 1.04 (0.89-1.21) | .62 |
| 3-7 y (SD/mo) | 0.96 (0.84-1.10) | .55 | 1.18 (0.95-1.48) | .14 |
| 7-10 y (SD/mo) | — | 1.04 (0.77-1.40) | .81 | |
| Weight | ||||
| Birth weight (SD) | 0.94 (0.84-1.06) | .29 | 0.93 (0.76-1.14) | .47 |
| 0-3 mo (SD/mo) | 1.11 (1.03-1.20) | .006 | 1.14 (1.00-1.31) | .05 |
| 3-12 mo (SD/mo) | 1.09 (1.00-1.19) | .05 | 1.24 (1.07-1.42) | .003 |
| 1-3 y (SD/mo) | 0.95 (0.87-1.04) | .23 | 0.87 (0.75-1.01) | .08 |
| 3-7 y (SD/mo) | 1.00 (0.91-1.10) | .96 | 1.09 (0.93-1.28) | .31 |
| 7-10 y (SD/mo) | — | 0.93 (0.74-1.17) | .52 |
Values are ORs (95% CIs) of bronchial responsiveness or reversibility. Models are adjusted for maternal age, education level, history of asthma, body mass index, parity, smoking during pregnancy, anxiety, and the child's sex, gestational age, breast-feeding duration, and previous height or weight gain. Models of weight were additionally adjusted for preceding height and weight growth trajectories, and models of height were additionally adjusted for preceding height growth trajectories and birth weight.
Methacholine responsive, Highest tertile versus lower tertiles; Salbutamol responsive, greater than 12% change in FEV1 vs less than 12% change.