Table E4.
Growth (height and weight) with lung function measures
| Mean difference (95% CI) |
||||
|---|---|---|---|---|
| Height growth |
Weight growth |
|||
| 8 y of age | 15 y of age | 8 y of age | 15 y of age | |
| FVC | ||||
| Birth | −0.002 (−0.039 to 0.035) | −0.142 (−0.187 to −0.096) | 0.081 (0.040 to 0.122) | 0.058 (0.008 to 0.108) |
| 0-3 mo | −0.013 (−0.042 to 0.016) | −0.049 (−0.084 to −0.014) | 0.061 (0.034 to 0.088) | 0.052 (0.019 to 0.085) |
| 3-12 mo | −0.004 (−0.044 to 0.037) | −0.052 (−0.101 to −0.004) | 0.065 (0.035 to 0.095) | 0.058 (0.022 to 0.095) |
| 1-3 y | −0.006 (−0.038 to 0.026) | −0.047 (−0.086 to −0.009) | 0.085 (0.054 to 0.116) | 0.073 (0.035 to 0.110) |
| 3-7 y | −0.009 (−0.055 to 0.037) | 0.001 (−0.054 to 0.056) | 0.114 (0.080 to 0.147) | 0.124 (0.083 to 0.165) |
| 7-10 y | −0.031 (−0.105 to 0.044) | 0.102 (0.047 to 0.158) | ||
| FEV1 | ||||
| Birth | 0.006 (−0.032 to 0.043) | −0.124 (−0.171 to −0.078) | 0.082 (0.041 to 0.124) | 0.026 (−0.025 to 0.077) |
| 0-3 mo | −0.011 (−0.04 to 0.018) | −0.055 (−0.091 to −0.019) | −0.014 (−0.041 to 0.013) | 0.039 (0.005 to 0.073) |
| 3-12 mo | 0.016 (−0.025 to 0.056) | −0.044 (−0.093 to 0.006) | 0.034 (0.004 to 0.064) | 0.057 (0.019 to 0.094) |
| 1-3 y | −0.008 (−0.040 to 0.024) | −0.05 (−0.090 to −0.011) | 0.092 (0.06 to 0.123) | 0.062 (0.024 to 0.101) |
| 3-7 y | −0.04 (−0.086 to 0.007) | 0.006 (−0.050 to 0.063) | 0.063 (0.029 to 0.096) | 0.112 (0.070 to 0.154) |
| 7-10 y | −0.015 (−0.092 to 0.062) | 0.060 (0.002 to 0.118) | ||
| FEF25-75 | ||||
| Birth | −0.003 (−0.041 to 0.034) | −0.029 (−0.073 to 0.015) | −0.014 (−0.056 to 0.027) | −0.072 (−0.121 to −0.022) |
| 0-3 mo | −0.006 (−0.034 to 0.023) | −0.023 (−0.057 to 0.011) | −0.114 (−0.142 to −0.087) | −0.048 (−0.081 to −0.015) |
| 3-12 mo | 0.014 (−0.027 to 0.054) | −0.021 (−0.068 to 0.027) | −0.052 (−0.082 to −0.021) | −0.031 (−0.067 to 0.005) |
| 1-3 y | −0.005 (−0.037 to 0.027) | −0.022 (−0.060 to 0.015) | 0.008 (−0.023 to 0.040) | −0.007 (−0.045 to 0.031) |
| 3-7 y | −0.055 (−0.101 to −0.009) | 0.016 (−0.038 to 0.07) | −0.088 (−0.122 to −0.054) | 0.004 (−0.039 to 0.047) |
| 7-10 y | 0.026 (−0.047 to 0.099) | −0.058 (−0.114 to −0.002) | ||
| FEV1/FVC ratio | ||||
| Birth | 0.015 (−0.027 to 0.057) | 0.051 (0.000328 to 0.101) | 0.001 (−0.040 to 0.042) | −0.077 (−0.122 to −0.031) |
| 0-3 mo | 0.007 (−0.029 to 0.044) | −0.032 (−0.074 to 0.011) | −0.129 (−0.155 to −0.102) | −0.041 (−0.071 to −0.010) |
| 3-12 mo | 0.037 (−0.008 to 0.082) | 0.027 (−0.025 to 0.080) | −0.058 (−0.088 to −0.028) | −0.021 (−0.054 to 0.013) |
| 1-3 y | 0.059 (0.008 to 0.109) | −0.026 (−0.086 to 0.034) | 0.018 (−0.014 to 0.049) | −0.002 (−0.037 to 0.033) |
| 3-7 y | 0.035 (−0.087 to 0.157) | 0.046 (−0.099 to 0.191) | −0.069 (−0.103 to −0.035) | 0.002 (−0.038 to 0.041) |
| 7-10 y | 0.009 (−0.075 to 0.093) | −0.067 (−0.119 to −0.016) | ||
| FEF25-75/FVC ratio | ||||
| Birth | −0.002 (−0.043 to 0.04) | 0.063 (0.016 to 0.109) | 0.048 (0.007 to 0.088) | −0.042 (−0.09 to 0.007) |
| 0-3 mo | 0.021 (−0.015 to 0.057) | −0.031 (−0.07 to 0.008) | −0.11 (−0.137 to −0.083) | −0.002 (−0.035 to 0.03) |
| 3-12 mo | 0.026 (−0.019 to 0.070) | 0.024 (−0.025 to 0.072) | −0.024 (−0.054 to 0.005) | 0.025 (−0.01 to 0.061) |
| 1-3 y | 0.048 (−0.002 to 0.098) | −0.020 (−0.075 to 0.035) | 0.062 (0.031 to 0.094) | 0.038 (0.002 to 0.075) |
| 3-7 y | −0.026 (−0.147 to 0.095) | 0.064 (−0.07 to 0.198) | −0.014 (−0.047 to 0.02) | 0.069 (0.029 to 0.109) |
| 7-10 y | 0.04 (−0.038 to 0.118) | 0.003 (−0.052 to 0.058) | ||
Values are differences in z score lung function (95% CIs). Z scores were calculated for sex, age, and height at the time of measurement. Models are adjusted for maternal age, education level, body mass index, parity, smoking during pregnancy, anxiety, history of asthma, and the child's sex, gestational age, and breast-feeding duration. Models of weight were additionally adjusted for preceding height and weight growth trajectories, and models of height were additionally adjusted for preceding height growth trajectories and birth weight. Models for lung function at 15 years of age were additionally adjusted for lung function measures at age 8 years.