Table E5.

Weight growth trajectories and lung function in strata of current body mass index

	FVC (z score)	P value	P value for interaction	FEV1 (z score)	P value	P value for interaction	FEF25-75 (z score)	P value	P value for interaction
8 y of age
Normal BMI at 8 y
Birth weight (SD)	0.072 (0.020 to 0.124)	.006	.85	0.062 (0.010 to 0.115)	.02	.77	−0.033 (−0.086 to 0.019)	.21	.99
0-3 mo (SD/mo)	0.056 (0.021 to 0.091)	.001	.13	−0.007 (−0.041 to 0.028)	.71	.03	−0.103 (−0.137 to −0.068)	<.001	.25
3-12 mo (SD/mo)	0.062 (0.023 to 0.101)	.002	.42	0.048 (0.008 to 0.087)	.02	.02	−0.024 (−0.063 to 0.015)	.23	.01
1-3 y (SD/mo)	0.086 (0.043 to 0.128)	<.001	.38	0.089 (0.046 to 0.132)	<.001	.52	0.007 (−0.036 to 0.050)	.76	.49
3-7 y (SD/mo)	0.293 (0.217 to 0.368)	<.001	<.001	0.266 (0.190 to 0.343)	<.001	<.001	−0.084 (−0.161 to −0.006)	.03	.01
7-10 y (SD/mo)
Overweight at 8 y
Birth weight (SD)	0.087 (0.014 to 0.160)	.02	.85	0.101 (0.027 to 0.175)	.01	.77	0.024 (−0.052 to 0.100)	.53	.99
0-3 mo (SD/mo)	0.035 (−0.014 to 0.083)	.16	.13	−0.025 (−0.074 to 0.025)	.33	.03	−0.086 (−0.137 to −0.035)	.001	.25
3-12 mo (SD/mo)	0.039 (−0.013 to 0.092)	.14	.42	−0.002 (−0.055 to 0.051)	.95	.02	−0.080 (−0.134 to −0.026)	.004	.01
1-3 y (SD/mo)	0.061 (0.008 to 0.114)	.03	.38	0.096 (0.043 to 0.150)	.001	.52	0.051 (−0.004 to 0.107)	.07	.49
3-7 y (SD/mo)	0.049 (−0.009 to 0.106)	.10	<.001	−0.010 (−0.069 to 0.049)	.733	<.001	−0.091 (−0.151 to −0.030)	.003	.01
7-10 y (SD/mo)
15 y of age
Normal BMI at 15 y
Birth weight (SD)	0.076 (0.021 to 0.131)	.007	.09	0.043 (−0.015 to 0.101)	.15	.22	−0.080 (−0.185 to 0.026)	.14	.64
0-3 mo (SD/mo)	0.022 (−0.015 to 0.059)	.25	.06	0.017 (−0.022 to 0.056)	.39	.11	−0.019 (−0.056 to 0.019)	.32	.08
3-12 mo (SD/mo)	0.037 (−0.005 to 0.078)	.08	.82	0.033 (−0.010 to 0.077)	.13	.85	0.016 (−0.025 to 0.057)	.45	.46
1-3 y (SD/mo)	0.055 (0.011 to 0.099)	.01	.01	0.046 (0.000 to 0.093)	.05	.22	0.035 (−0.009 to 0.079)	.12	.17
3-7 y (SD/mo)	0.192 (0.131 to 0.252)	<.001	<.001	0.218 (0.154 to 0.281)	<.001	<.001	0.178 (0.117 to 0.238)	<.001	<.001
7-10 y (SD/mo)	0.110 (0.041 to 0.180)	.002	<.001	0.072 (−0.002 to 0.145)	.06	<.001	−0.008 (−0.078 to 0.061)	.81	<.001
Overweight at 15 y
Birth weight (SD)	−0.036 (−0.146 to 0.074)	.52	.09	−0.052 (−0.161 to 0.057)	.35	.22	−0.032 (−0.087 to 0.023)	.26	.64
0-3 mo (SD/mo)	0.127 (0.055 to 0.200)	.001	.06	0.098 (0.025 to 0.170)	.008	.11	0.050 (−0.021 to 0.121)	.17	.08
3-12 mo (SD/mo)	0.055 (−0.023 to 0.134)	.17	.82	0.079 (0.001 to 0.156)	.048	.85	0.036 (−0.040 to 0.112)	.35	.46
1-3 y (SD/mo)	0.047 (−0.029 to 0.124)	.23	.01	0.062 (−0.014 to 0.138)	.11	.22	0.034 (−0.041 to 0.108)	.37	.17
3-7 y (SD/mo)	−0.057 (−0.137 to 0.022)	.16	<.001	−0.041 (−0.120 to 0.038)	.31	<.001	−0.051 (−0.128 to 0.026)	.19	<.001
7-10 y (SD/mo)	0.036 (−0.070 to 0.143)	.51	<.001	0.040 (−0.064 to 0.145)	.45	<.001	0.043 (−0.060 to 0.146)	.41	<.001

Values are differences in z score lung function (95% CIs). Z scores were calculated for sex, age, and height at the time of measurement. Models are adjusted for maternal age, education level, body mass index, parity, smoking during pregnancy, anxiety, history of asthma, and the child's sex, gestational age, and breast-feeding duration. Models of weight were additionally adjusted for preceding height and weight growth trajectories, and models of height were additionally adjusted for preceding height growth trajectories and birth weight. Models for lung function at age 15 years were additionally adjusted for lung function measures at age 8 years.