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. 2015 Jun 1;10(6):e0129824. doi: 10.1371/journal.pone.0129824

Table 2. Subgroup analyses for circulating adiponectin and endometrial cancer risk.

No. of studies RR (95% CI) P(Z) I 2 P(Q) Reference
Overall 11 0.47 (0.33–0.66) <0.001 67.5% 0.001 [1121,30]
District
    Asia 3 0.54 (0.37–0.80) 0.002 0.0% 0.943 [17,18,21]
    Europe 3 0.31 (0.13–0.73) 0.007 70.2% 0.035 [11,13,15]
    North-America 5 0.51 (0.27–0.95) 0.034 82.6% <0.001 [12,14,16,19,20]
Menopausal status
    Pre 3 0.92 (0.45–1.87) 0.807 29.1% 0.244 [11,13,19]
    Post 7 0.50 (0.33–0.76) 0.001 53.8% 0.043 [11,13,15,16,1820]
    Combined 4 0.34 (0.18–0.66) 0.001 72.8% 0.012 [12,14,17,21]
Adjustment factors
    Age
    Yes 7 0.34 (0.21–0.54) <0.001 64.8% 0.009 [11,12,14,15,17,18,21]
    No 4 0.71 (0.47–1.07) 0.099 53.9% 0.089 [13,16,19,20]
    BMI
    Yes 9 0.45 (0.28–0.73) 0.001 73.7% <0.001 [1113,15,1721]
    No 2 0.47 (0.35–0.64) <0.001 0.0% 0.948 [14,16]
    hypertension
    Yes 5 0.35 (0.16–0.74) 0.006 73.3% 0.010 [12,14,18,21]
    No 6 0.54 (0.36–0.81) 0.002 64.2% 0.010 [11,13,1517,19,20]
    diabetes
    Yes 5 0.44 (0.22–0.91) 0.027 78.4% 0.001 [12,16,18,19]
    No 6 0.48 (0.33–0.71) <0.001 58.8% 0.033 [11,1315,17,20]

RR, relative risk; CI, confidence interval; pre, premenopause; post, postmenopause; BMI, body mass index.