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Glycol chitin-Progesterone (GC-P4) hydrogel. (a) Solubility of P4 in GC solutions. P4 solubility proportionally increased with increasing GC concentration, (n = 4). (b) 0.1%, (w/v) P4 loaded into 5% GC at pH 4.2 (GC-P4) maintains a Tgel near body temperature. (c) Gelation of GC-P4 within seconds after exposure to vaginal temperature (37°C).
