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. 2015 Mar 9;106(5):481–488. doi: 10.1111/cas.12630

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© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Fig 2 — Induction of the epithelial–mesenchymal transition (EMT) by transforming growth factor (TGF)-β through transcriptional regulation of miRNAs and transcription factors. TGF-β directly or indirectly upregulates the key EMT regulators at the transcriptional level, and appears to modulate expression of miRNAs that target the key EMT regulators. δEF1, δ-crystallin/E2-box factor 1; EGF, epidermal growth factor; HMGA2, high mobility group AT-hook 2; ZEB1, zinc finger E-box binding homeobox 1.