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Schematic illustrations of a double-negative feedback loop and the ceRNA pathway. Expression levels of the key EMT regulators and miRNAs suppress each other. Some of the key EMT regulators function as ceRNAs. δEF1, δ-crystallin/E2-box factor 1; HMGA2, high mobility group AT-hook 2; PTEN, phosphatase and tensin homolog; SIP1, Smad-interacting protein 1; TGF-β, transforming growth factor-β; ZEB1, zinc finger E-box binding homeobox 1.
