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Schematic illustrations of epithelial–mesenchymal transition (EMT) regulated by transcriptional and post-transcriptional mechanisms. The key EMT regulators decrease expression of epithelial splicing regulatory proteins (ESRPs), leading to changes in alternative splicing events. FGFR, fibroblast growth factor receptor; FSP, fibroblast-specific protein; SMA, smooth muscle α-actin; ZEB, zinc finger E-box binding homeobox.
