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. 2015 Mar 25;106(5):576–583. doi: 10.1111/cas.12648

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© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Fig 5 — Catechol-O-methyltransferase (COMT) suppresses pancreatic tumor growth in BALB/c nude mice. (a) Gross appearance of pancreatic tumors from BALB/c nude mice in four groups. COMT-miR, COMT protein silencing cell lines; COMT-OE, COMT protein overexpression cell lines; Control-miR, control for COMT-miR cell lines with normal COMT protein expression; Control-OE, control for COMT-OE cell lines with normal COMT protein expression. (b) Illustration of Ki-67-positive cells in specimens of the xenograft model with different central necrotic lumen diameters. (c) Volume of tumors in each group. *P < 0.01; **P < 0.01. (d) Weight of tumors in each group. *P < 0.05; **P = 0.0585. (c, d) Error bars indicate SD.